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How increased oxygenation can assist recovery from inflammatory disease

If you've ever traveled to a mountain resort or done any high-altitude sports, you know that the “thin air” has an effect on our bodies.  High altitude air has the same percentage of oxygen by volume as sea level air, but because the atmospheric pressure is lower in the mountains, oxygen molecules are more sparse.  This means with every breath you take, you’re getting less oxygen.  “Altitude sickness” includes problems sleeping, fatigue, headaches, and even life-threatening pulmonary edema (buildup of fluids in the lungs).   Technically the signs of altitude sickness can begin at elevations of 5000 feet above sea level.  We know that the amount of oxygen in every breath you take is very important for people with good health; and even more so for people whose health has been compromised by biotoxins or injury.

Sadly, we understand that many of our clients come to us because they are going through mold or other biotoxin illness and know first-hand how damaging the effects can be.  One such illness is called Chronic Inflammatory Response Syndrome (CIRS), which was defined by Dr. Ritchie Shoemaker in the 1990’s.  He pioneered a treatment protocol that many doctors use today to help their patients recover from this syndrome.  Steps 8 and 9 relate to improving oxygen delivery to cells to decrease inflammation.  Although he does not prescribe respiratory methods for increasing oxygenation (it’s more through detoxification, supplements and correcting enzymes), studies have shown that supplemental oxygen can benefit CIRS patients.  

Biotoxins are extremely small, fat soluble molecules capable of going from cell to cell through membranes without being carried directly in the blood stream rendering them impossible to find in the blood stream. Biotoxins can enter through inhalation, direct contact with contaminated water, ingestion, tick bites and spider bites. These biotoxins, in genetically susceptible people whose immune system (antibodies) do not recognize and tag them, lead to chronic inflammation and long lasting chronic illness. Biotoxins bind to certain surface receptors, particularly those on white blood cells (macrophages, monocytes and dendritic cells) called antigen presenting cells. (Chronic Inflammatory Response Syndrome (CIRS) Evaluation and Treatment)

Why more oxygen?

Hypoxia (low oxygen in body tissues) can cause inflammation; for example, in persons with mountain sickness, levels of circulating proinflammatory cytokines increase, and leakage of fluid (“vascular leakage”) causes pulmonary or cerebral edema.  The reverse is also true: inflammation can cause hypoxia, such as in inflammatory bowel disease, where the entire mucosa becomes even more hypoxic.  Basically the inflammation is preventing oxygen from reaching capillaries.  Therefore inflammation and hypoxia can be interdependent. (2021 study Hypoxia and Inflammation)

In conjunction with biotoxin “detoxing” treatments, then, it’s possible that other ways of increasing oxygen could reduce inflammation.  Following are some ways proven to increase oxygenation of your cells.

• Moderate exercise (as approved by your doctor) can be a good way to bring more oxygen to your cells and reduce inflammation.  This 2010 review shows how many studies have linked exercise with lowering of C-reactive protein (CRP) levels, which are a marker of inflammation.  This 2021 article cites benefits of exercise to sufferers of other chronic inflammatory diseases such as coronary heart patients and type 2 diabetes patients.  Although your oxygen levels may drop slightly during exercise, in the long run, exercise results in increased levels of arterial oxygen levels at rest, which will bring more oxygen to all of your cells. (Adjustments during exercise)

• Deep-breathing techniques are helpful to everyone, not just those with chronic inflammation.  Check out our article for more information on breathing exercises that you can do without specialized equipment, and this article for devices that help improve breathing too. 

• ELO water (a commercially available oxygen-enriched bottled drinking water ) was shown to increase arterial blood oxygen levels, improved cellular oxygenation and altered markers of mitochondrial function in rats, and was recommended as an effective adjuvant therapy even in people with longstanding diabetes already on insulin. The following charts show that this particular bottled water does indeed have higher dissolved oxygen (DO) than standard tap water, even with the bottle left open for a week.  (2021 study)

• This 2022 study showed improvement of 75% of 49 dogs who suffered from Systemic Inflammatory Response Syndrome (SIRS) and were given HBOT sessions.  

• Hyperbaric oxygen therapy (HBOT) has several positive effects on inflammation:

• it may be able to stop certain types of fungus from growing in our bodies (studies). 

• It promotes a strong immune system

• It allows the brain to heal, improving memory and cognitive issues)

• reduces inflammation on the cellular level by increasing anti-inflammatory cytokines and helps accelerate fibroblast activation.

• Supplemental oxygen through a face mask or cannula and portable cannisters should only be prescribed by a doctor, because supplemental oxygen in those who are getting enough oxygen (healthy subjects) can cause airway inflammation and oxidative stress, quite the opposite of what is desired.

• Continuous Positive Airway Pressure machines (CPAPs) do not increase the percentage of oxygen in the air you are breathing in; they just pressurize ambient air so that your airways stay open while you sleep.  However, if you have sleep apnea or problems getting enough air while you sleep, check with your doctor to see whether a CPAP would be helpful.

• Another way to increase oxygenation safely is achieved with dedicated air-sealing and adding oxygen to your bedroom.  We’ve written an article on how Altitude Control Technology can increase the oxygen supply to your bedroom, so that your resting and sleeping hours are more productive in terms of healing your body. 

• Although such systems are an investment, if you plan on staying in your home it could benefit you in the long term.

• We’ve also laid out some alternatives in the article for increasing oxygen in your bedroom and home by increasing ventilation from outside.

Taking care of your body’s air filters

A little bit of knowledge about our bodies really makes us appreciate all their functions and complexities!  Take for example our respiratory system starting with the nose.  It’s important to understand how our nose and sinuses work.  If you’re not an Ear, Nose and Throat (ENT) doctor and you want to learn how air gets to your lungs, here is a very helpful video.  (It’s made by a clinic on the US west coast that does not do surgeries, yet they are able to help their patients by thoroughly examining and diagnosing the nasal structure and breathing and recommending treatment from there).  The video also illustrates the point that we need to utilize ALL of the area and defenses in our nasal passages to help us breathe, fight infection, smell and taste, and to be careful about removing or reducing any one spot so that nasal flow is not redirected too radically.

Here are the main defenses that are built into our body to prevent contamination by particulates in the air:

1. Hairs in your nose entrap larger particles, which can be blown out 
2. Mucus in the nasal passages entraps smaller particles as air bounces off mucus-lined surfaces
3. Moderate resistance from undulating passages in the nose causes the air to be slightly turbulent and capture more particles
4. Tiny hairs, called cilia, along your air passages move in a sweeping motion to keep the passages clean.
5. Sinuses produce the mucus and warm and humidify the air going down to your lungs.

A lot of peoples’ breathing problems originate in the sinuses. 

Sinuses are admittedly a bit of a mystery (nysinuscenter.com).  We do know that they generate mucus to moisten our nasal pathways, and they give resonance to our voice (with a plugged nose our voices sound very different).  We each have 4 sets of sinuses, which are normally empty except for warm, moist air and a small amount of mucus.  There are small pathways into and out of each sinus cavity, called ostia.  Knowing these few details, then, tells us that we don’t breathe through our sinuses, yet, when they get plugged with mucus or inflamed with infection, they can swell and severely obstruct  nasal passages.  Here is a diagram of the sinuses and how blocking the ostia can promote infection and swelling:

Source: Navage.com

There are several non-medicated ways that doctors may suggest to take care of your sinuses and nasal passages, to keep them performing well and protecting our respiratory system.  Some of these are nasal sprays, nasal irrigation, humidifiers, steams and saunas, and staying hydrated.

Nasal sprays at the minimum are saline solutions packaged in a spray bottle.  To use a nasal spray, block off one nostril by applying gentle pressure to the side of the nose, insert the tip of the bottle into the other nostril, and squeeze the bottle forcefully while inhaling through your nose.  Then spray the other side, making sure to block the opposite nostril.  The saline solution moistens the nasal passages and helps the mucus to stay thin so that it flows down the back of your throat and doesn’t plug the ostia. Various chemicals are added to some nasal sprays to shrink membranes and provide longer-lasting moisture, but in general these are not necessary for a healthy individual.  It’s a great idea to use nasal sprays when the humidity is low, or you’re traveling in close proximity to other people, to keep your nasal passages moist and able to discharge microbes easily.  

Nasal sprays with essential oils (EOs) have been observed to lessen symptoms of allergenic rhinitis (AR).  Rhinitis is when a reaction occurs that causes nasal congestion, runny nose, sneezing, and itching. Most types of rhinitis are caused by inflammation and are associated with symptoms in the eyes, ears, or throat. (hopkinsmedicine.org)  In a 2021 study using Puressentiel® Respiratory-Decongestant Nasal Spray (PRDNS), which is a spray containing 4 essential oils, 43 patients with persistent mild or persistent moderate-to-severe AR used the spray 1x in the morning and 1x in the evening for 30 days.  They were tested at Day 0 (before treatment) and Day 30 for Allergic Rhinitis Control Test (ARCT) scores. The proportion of patients with controlled rhinitis after 30 days of treatment with intranasal PRDNS administration was 69.8% versus 14% before treatment.

This is great news, and you can even DIY your own Essential Oil nasal spray to fight mold and microbes.  This video by Dr. Jill Crista, a naturopathic doctor and one of the leading experts in mold-related illness, shows how to do this.  Personally, I buy a generic 1.5 oz plain saline spray, pop the top off, add only 1 drop of food-grade teatree oil or 1 drop of oregano oil, replace the top and shake to make a strong mold killer for those days when I’ve been exposed to too much mold or start to feel a cold coming on.. 

Why irrigate?

Irrigation does several things: 

• it gets the harmful particles like viruses, bacteria and mold out more quickly than your body can do it alone, reducing the chances of infection

• It can help clear the ostia so that sinuses can maintain natural drainage and not become blocked

• it clears the cilia so they are not overloaded with thick mucus or particles.

• The salts in the sinus rinse shrink inflamed sinus tissue by pulling out water.

According to navage.com, a nasal irrigant manufacturer: “There is no clinical evidence that saline from nasal irrigation devices of any type consistently enters into and rinses inside the frontal, sphenoid, and ethmoid sinus cavities. Nasal irrigation can and often does penetrate the maxillary sinuses with saline.”  So, although many irrigations are marketed as “sinus rinses”, they technically only go into 1 out of 4 sets of sinuses. 

There are several nasal irrigation systems, some of which are called Navage (a powered suction saline system), neti pots, and a nasal squeeze bottle. Here is an excellent video on how to irrigate your nose using a squeeze bottle.   

Humidifiers, steam and saunas do help to open nasal passageways temporarily.  Warm moist air causes the blood supply to your respiratory mucous membrane to improve. This means they are better able to purify themselves, which in turn strengthens your natural defense mechanisms. Your bronchial muscles also relax in the warm air – a great benefit for those suffering from asthma or bronchitis. (klafs.com)  If you do use a humidifier, take care to clean it regularly, as it can breed mold and bacteria.  In addition, ultrasonic humidifiers can actually increase the PM2.5 levels in your indoor air (see our post here). 

According to healthline.com, besides using moisture in the air, make sure you help your body from the inside by staying hydrated.  Drinking plenty of fluids like water or tea — especially if you have a dry nose during a cold — can help moisturize your nose from the inside out.

Just like any filter, occasional maintenance is needed, and your body is no exception!  We hope that you stay well throughout the year and keep those nasal passages clean and moist for your best breathing.